This paper aims to 'translate' the methods for estimating a HR and associated statistics from published time-to-event-analyses into less statistical and more practical guidance and provide a corresponding, easy-to-use calculations spreadsheet, to facilitate the computational aspects.
Awareness and adoption of these methods is somewhat limited, perhaps because they are published in the statistical literature using statistical notation. In the absence of individual patient data (IPD), methods are available to obtain HRs and/or associated statistics by carefully manipulating published or other summary data. In systematic reviews and meta-analyses, time-to-event outcomes are most appropriately analysed using hazard ratios (HRs).
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